Selenium represents an adjuvant that selectively sensitizes cancer cells to these treatments modalities, potentially by inducing lipid peroxidation. Calmodulin antagonists also decreased the cytochrome p450 content of microsomes. Topical antioxidant vitamins c and e prevent uvbradiation. Ionizing radiation is known to induce oxidative stress through generation of reactive oxygen species ros resulting in imbalance of the prooxidant and antioxidant activities ultimately resulting in cell death. Efforts are made to show similarities between radiolytic and. Ionizing radiation is classified as either electromagnetic or particulate. Radiation induced peroxidative damage semantic scholar. Request pdf radiation induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers although radiation is widely used to treat cancers, resistance mechanisms often. The ability of curcumin, a natural antioxidant from turmeric, to inhibit radiationinduced lipid peroxidation in rat liver microsomes was examined. Pdf antioxidant capabilities of scoparone, the component of artemisia scoparia and other medicinal plants, against lipid peroxidation induced by. Leaf extract of moringa oleifera prevents ionizing.
It is the interaction of these radiationinduced free radicals with important biomolecules within the cell that is the basis of the cellular sensitivity to radiation. Inhibition of radiationinduced lipid peroxidation by curcumin in n20 saturated rat liver microsomes. Radiationinduced lipid peroxidation triggers ferroptosis and. Methylseleninic acid induces lipid peroxidation and radiation. Pdf inhibition of radiationinduced lipid peroxidation. Ionizing radiationinduced metabolic oxidative stress and. Antioxidant activity of capsaicin on radiationinduced. Inhibition of radiationinduced lipid peroxidation by. Antioxidant activity of capsaicin on radiationinduced oxidation of murine hepatic mitochondrial membrane preparation ramachandran gangabhagirathi,1 ravi joshi,2 1bioorganic division, 2radiation and photochemistry division, bhabha atomic research center, trombay, mumbai, india abstract. Pdf protective effect of moringa oleifera leaf extract mole against radiationinduced lipid peroxidation has been investigated.
Radiation induced lipid peroxidation in liposomes sciencedirect. Modulation of radiation induced lipid peroxidation by phospholipase. Effects of calmodulin antagonists on radiationinduced. Radiation induced peroxidation and fragmentation of lipids in a model membrane. Ionizing radiation track structure and the nature of induced biological effects ionizing radiation is classified as either electromagnetic or particulate. Curcumin was incorporated into microsomes during ultracentrifugation. The antioxidant has significant time and concentrationdependent inhibitory effect on lipid peroxidation induced by rradiation. Protective effect of moringa oleifera leaf extract mole against radiationinduced lipid peroxidation has been investigated. Additional methods and supplemental figures and tables pdf. Capsaicin is the major capsaicinoid in chili peppers and is widely used as a spice. We report here that ferroptosis, a form of nonapoptotic cell death driven by lipid peroxidation, is partly responsible for radiationinduced cancer cell death. Inhibition of radiation induced lipid peroxidation by tetrahydrocurcumin.
Ionizing radiation track structure and the nature of induced biological effects. Radiationinduced lipid peroxidation triggers ferroptosis. Lipid peroxidation is shown to have importance in understanding the modifications of radiation effects. Although radiation is widely used to treat cancers, resistance mechanisms often develop and involve activation of dna repair and inhibition of apoptosis. Pdf protective effect of moringa oleifera leaf extract mole against radiation induced lipid peroxidation has been investigated. Swiss albino mice were administered mole 300 mgkg of body weight for 15 consecutive days before exposing them to a single dose of 5 gy of 60 co. Lipid peroxidation after ionizing irradiation leads to apoptosis and. Pdf amelioration of ionizing radiation induced lipid peroxidation in. These results suggest that ferroptosis and lipid peroxidation contribute to radiationinduced cell death in ht1080 cells, and that this ferroptotic cell death can be enhanced by the addition of otherwise sublethal concentrations of ike or rsl3. We report here that ferroptosis, a form of nonapoptotic cell death driven by lipid peroxidation, is partly responsible for. Vitamin e and vitamin c completely protected against uvbradiationinduced lipid peroxidation p pdf 51 k pdf plus 97 k citing articles. Pdf scoparone inhibits ultraviolet radiationinduced lipid. When the microsomes are irradiated in the presence of n20, the resulting lipid peroxidation is predominantly due to hydroxyl radicals. We have studied the effect of ferrous ions on radiation induced lipid peroxidation.
Pdf influence of ferulic acid on gammaradiation induced. Request pdf radiationinduced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers although radiation is widely used to treat cancers, resistance mechanisms often. Radiationinduced lipid peroxidation triggers ferroptosis and synergizes. Amelioration of ionizing radiation induced lipid peroxidation. Lipid peroxidation was found to increase with increase in concentrations of ferrous ions fig. Inhibition of radiationinduced lipid peroxidation by tetrahydrocurcumin. Radiationinduced lipid peroxidation and membrane permeability.
1158 120 110 1100 899 971 419 509 1030 154 595 1126 1310 1146 1059 329 1443 1018 818 417 1230 972 351 151 447 214 530 431 1032 330 1407 332 974 1019 172 978 1049 1234 847 1185 410 1419